High levels of blood, bile and urine is achieved after a single “administration. The table shows serum cefoperazone concentrations in healthy adult volunteers after 15 minutes uniform / in infusion 1, 2, 3 or 4 grams of the drug, or a single a / m of 1 or 2 grams of the drug.
The average half-life of cefoperazone from serum is deca durabolin for sale approximately 2 hours and is not dependent on mode of administration.
Cefoperazone reach therapeutic concentrations in all investigated body fluids and tissues, including, ascitic and cerebrospinal (meningitis) liquid, urine, bile and wall cholic bladder, lung and sputum, tonsils and mucosa of the sinuses, ears fibrillation, kidney, ureter, prostate, testis, uterus and fallopian tubes, the bones, the blood of the umbilical cord and amniotic fluid. Is excreted in bile and urine.Typically, the concentration of the drug in bile reaches a maximum after 1-3 h after administration and the serum exceeds 100 times the concentration. Concentration cefoperazone in the bile ranged from 66 ug / mL 30 min to 6000 g / ml 3 hours after / in the bolus of 2 g of the drug to patients not suffering a blockage of the bile ducts.
After 12 hours after the administration of different dosages of the various ways in individuals with normal kidney deca durabolin for sale function with urine output by an average of 20-30% of cefoperazone. After 15 minutes on / in infusion of 2 g of cefoperazone drug concentration in urine greater than 2,200 micrograms / ml. After the / m of 2 g, maximum concentrations in urine were approximately 1000 mcg / ml.
In healthy people, the re-introduction of cefoperazone not bait to cumulation. In patients with impaired liver function increases the half-life of the drug from the blood serum and urinary excretion. In patients with renal insufficiency, hepatic cefoperazone may accumulate in the serum. The maximum serum concentration, area under the concentration-time curve and the half-life of blood serum are the same as in healthy individuals and in patients with renal insufficiency.
Indications Monotherapy for the treatment of the following infections caused by microorganisms sensitive to cefoperazone:
- Infections of the upper and lower respiratory tract
- Infections of the upper and lower urinary tract
- Peritonitis, cholecystitis, cholangitis and other intra-abdominal infections
- Infections of the skin and soft tissues
- Bone and deca durabolin for sale joint infections
- Inflammatory diseases of the pelvic organs, endometritis, gonorrhea and other genital tract infections
Prevention infektsyonnyh postoperative complications in abdominal, gynecological, cardiovascular and orthopedic surgery. Combination therapy with broad spectrum of action allows cefoperazone monotherapy with most infections, but ceftazidime may also be used in combination with other antibiotics.
Hypersensitivity to cefoperazone, as well as an indication of allergic reactions to cephalosporins in history.
Pregnancy and lactation
Use in pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus. If necessary, the appointment during lactation should stop breastfeeding.
Dosage and administration: Adults 2-4 g / day in equal deca durabolin for sale parts every 12 hours. In severe infections occurring dose may be increased up to 8 g / day in equal parts every 12 hours. With the introduction of 12 g / day or even 16 g / day in equal parts every 8 h did not reveal any complications. Drug treatment can begin before the results of the study the susceptibility of microorganisms.