deca steroids

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The absorption is high, is rapidly absorbed from the gastrointestinal tract. The period of maximum concentration -30-60 minutes, the connection with plasma proteins – 15%. It penetrates through the blood-brain barrier. Size volume distribution and bioavailability newborns and children is similar to that of adults.
It is metabolized in the liver: 80% unreactive conjugation with glucuronic acid and sulphates to inactive metabolites; 17% undergoes hydroxylation with formation of active metabolites which are conjugated with glutathione to form inactive metabolites. With a lack of glutathione, these metabolites may block the enzyme hepatocyte deca steroids system and cause their death. In newborns the first two days of life, and children 3-10 years, the main metabolite of paracetamol sulphate is paracetamol in children 12 years and older – conjugated glucuronide.
The half-life – 2-3 hours. Within 24 hours, 85-95% of paracetamol excreted by the kidneys in the form of glucuronides and sulfates, unchanged – 3%. No significant differences in age elimination rate of paracetamol and in a total amount of the drug that is excreted in the urine, no.

Indications

Apply in children from 3 months to 12 years as:

 

  • antipyretic with acute respiratory diseases, flu, childhood infections, post-vaccination reactions and other conditions accompanied by fever;
  • analgesic for pain syndromes of mild to moderate intensity, including: headache, toothache, muscle pain, neuralgia, pain in trauma and burns.

In children between 1 and 3 months of possible single dose of the drug to reduce the temperature after vaccination, the preparation for all possible indications on prescription

Contraindications

Hypersensitivity to the drug, deca steroids age – up to 1 month of age.

Carefully

Violations of the liver and kidney function, Gilbert’s syndrome, Dubin-Johnson and Rotor, blood disease (anemia, thrombocytopenia, leukopenia), the genetic absence of glucose-6-phosphate dehydrogenase.

Dosing and Administration

Rectal. After a spontaneous bowel movement or enema, suppository, free from blisters and injected into the rectum. Dosage depends on the age and body weight, according to the table. A single dose of 10-15 mg / kg body weight, 2-3 times daily, 4-6 hours. The maximum daily dose of paracetamol should not exceed 60 mg / kg body weight.

Side effect

Nausea, vomiting, abdominal pain.
Allergic reactions (itching, rash on the skin and mucous membranes, urticaria, angioedema).
From the side of blood – anemia, leukopenia, agranulocytosis, thrombocytopenia.
With prolonged use at high doses – hepatotoxic and nephrotoxic (interstitial nephritis and papillary necrosis), effects, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia.

Interaction with other drugs

Stimulants microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumetsinol, rifampin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increases the production of hydroxylated active metabolites, which leads to the possibility of severe intoxication, even with a small overdose. Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity.When taken together with salicylates nephrotoxicity of paracetamol increases. Combination with chloramphenicol, increases the toxic properties of the latter. Enhances deca steroids the effect of indirect anticoagulants, reduces the effectiveness of uricosuric drugs.

special instructions

With continued fever for more than 3 days or pain for more than 5 days, contact your doctor.
You should avoid simultaneous use of paracetamol with other paratsetamolsoderzhaschimi drugs, as it may cause an overdose of paracetamol.

In applying the drug over 5-7 days should monitor the peripheral blood and functional liver condition. Paracetamol distorts performance laboratory tests for the quantitative determination of glucose and uric deca steroids acid in plasma.