durabolin

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The maximum plasma concentration (C max ) in adults after oral administration at a dose of 400 mg is achieved in 3-4 hours and is 2,5-4,9 g / ml, after taking a dose of 200 mg – 1,49-3, 25 mcg / ml. Eating on the absorption of the drug from the gastrointestinal tract does not have a significant impact. Distribution The volume durabolin of distribution when administered 200 mg of cefixime was 6.7 liters, when the equilibrium concentration – 16.8 liters. The plasma protein binds about 65% of cefixime. The highest concentrations in the urine creates cefixime and bile. Cefixime crosses the placenta. The concentration of cefixime in the umbilical cord blood reached the concentration of the drug in the mother’s blood plasma; the drug in breast milk is not determined. Metabolism and elimination half-life in children and adults is 3-4 hours Cefixime is not metabolized in the liver.; 50-55% of the dose is excreted in the urine unchanged within 24 hours. About 10% of cefixime is excreted in the bile. Pharmacokinetics in special clinical situations In the presence of renal insufficiency can be expected to increase the half-life and, accordingly, a higher concentration of the drug in plasma and slow its elimination by the kidneys. In patients with a creatinine clearance of 30 ml / min with 400 mg of cefixime increases half-life to 7-8 hours, the maximum plasma concentration averaged , and the urinary excretion per 24 hours -5.5%. In patients with liver cirrhosis the half-life increases to 6.4 hours, time to maximum concentration ; at the same time increasing the share of the drug is eliminated by the kidneys.  Area under the curve does not change.

Indications
Infectious-inflammatory diseases caused by durabolin susceptible to malaria infections:

  • streptococcal pharyngitis and tonsillitis;
  • sinusitis;
  • acute bronchitis;
  • exacerbation of chronic bronchitis;
  • acute otitis media;
  • uncomplicated urinary tract infections;
  • uncomplicated gonorrhea;
  • shigellosis.

 

Contraindications

  • Hypersensitivity to cefixime or components of the drug;
  • hypersensitivity to penicillins or cephalosporins;
  • not recommended for use in children with chronic renal failure in children weighing less than 25 kg, the dosage form

 

With care
the elderly, renal failure, colitis (in history), pregnancy.

Pregnancy and lactation
Use of the drug during pregnancy Tseforal durabolin possible when the expected benefit to the mother outweighs the potential risk to the fetus. If necessary, use during lactation should stop breastfeeding.

Dosing and dose
for adults and children weighing more than 50 kg the daily dose is 400 mg in one or two steps.
For children weighing 25-50 kg drug is given in a dose of 200 mg per day in one portion.
The tablet can be swallowed, squeezed sufficient water, or to dissolve in water and drink the resulting slurry immediately after preparation. The drug can be administered independently from the meal.
The duration of treatment depends on the nature of the disease and the type of infection. After the disappearance of symptoms of infection and / or fever, it is advisable to continue taking the drug for at least 48-72 hours.
The course of treatment for infections of the respiratory tract and durabolin is 7-14 days.
When tonzillofaringit caused by  pyogenes, duration of treatment should be . at least 10 days
in uncomplicated gonorrhea drug administered in a dose of 400 mg once daily.
in uncomplicated infections of the lower urinary tract in women drug can be administered for 3-7 days in uncomplicated infections of the upper urinary tract in women – 14 days.
in uncomplicated infections of the upper and lower urinary tract in men duration of treatment is 7-14 days.
If the kidney function the dose adjusted according to the creatinine clearance in the blood serum. When creatinine clearance 21-60 ml / min or in patients on hemodialysis, it is recommended to use other dosage forms of the drug due to the need to reduce the daily dose by 25%. If creatinine clearance of 20 ml / min or less and in patients undergoing peritoneal dialysis, the daily dose should be durabolin reduced by 2 times.