In patients with renal failure – no more than 2 grams per day. When an isolated hepatic impairment dose reduction is required, unless the patient receives the maximum dose, as compensatory renal excretion of the drug is increased to 90% or more.
In children – at daily doses of 50 to 200 mg / kg in 2-3 doses (every 8-12 hours); newborn (at least 8 days) the daily dose of 50-200 mg / kg divided nandrolone decanoate into 2 doses and administered every 12 hours.
In infants and children with severe infections, including bacterial meningitis, daily doses up to 300 mg / kg, shall be applied without complications.
Terms of preparation of the solution and administration
Intramuscular. For the preparation of solutions for intramuscular injection can be used the following solvents:
– water for injection;
– 0.9% sodium chloride solution,
which was added to 1 g of cefoperazone in a volume of 3 ml. When using lidocaine hydrochloride (! Without allergy to local anesthetics) was prepared in two stages: a primary dilution cefoperazone 1 g water for injection was added in the amounts indicated below, and the vial is shaken to complete dissolution of the powder; to this solution was added the required amount of 2% lidocaine hydrochloride solution and stirred. Est lidocaine concentration in the resulting solution – 0.5%.
The resulting solution is nandrolone decanoate injected deep intramuscularly in the areas of the body with pronounced muscular layer (the upper-outer quadrant of the buttock or the lateral surface of the thigh).
Intravenous administration . General recommendations . The contents of the vial are dissolved in sterile water for injection or in one of the following solutions in compatible / in: – 5% dextrose solution; – 0.9% sodium chloride solution; – lactate Ringer’s solution; – 10% dextrose; -. an aqueous solution containing 0.9% sodium chloride and 5% glucose to facilitate dissolution recommended 5 ml solvent per 1 g of cefoperazone. The solution was then further diluted with a compatible solutions into / in. When direct (stylus) intravenously maximum single dose cefoperazone adult is 2 g and for children about 50 mg / kg body weight. To prepare the solution for I / jet injection into the vial of the dry powder of the antibiotic (1 g) was added 10 ml of water for injection or other compatible solvent. Injected slowly, over 3-5 minutes. To drip nandrolone decanoate intravenous administration of 1 g of cefoperazone was dissolved in 5 ml of sterile water for injection, the resulting solution was added to 20-100 ml of a compatible infusion solution. Duration of administration depending on the volume of the solution may be 10-30 minutes or more. Freshly cefoperazone solutions are stable for 24 hours at 25 ° C.
Side effects: Allergic reactions : rash, maculopapular rash, fever, eosinophilia, erythema multiforme, a malignant exudative erythema (Stevens-Johnson syndrome), false-positive direct Coombs test. From the digestive system : nausea, vomiting, diarrhea, pseudomembranous colitis. From the side of hematopoiesis and the system of hemostasis : transient anemia, transient neutropenia (with prolonged treatment), eosinophilia, decreased hemoglobin and hematocrit, hypoprothrombinemia, increased prothrombin time. Laboratory findings : increased activity of “liver” transaminases and alkaline phosphatase, hypercreatininemia. Local reactions : with a / in introduction – phlebitis; when i / m administration – pain at the injection site.