Relationship to plasma proteins – 82-93%. The time to maximum concentration after intramuscular – 1.2 h after intravenous – at the end of infusion. The maximum concentration in the serum after intramuscular administration , after a single intravenous administration in the urine after intramuscular or intravenous administration (1 g) – 1000 ug / ml.
Reaches therapeutic concentrations in tissues and body fluids: peritoneal, ascitic fluid, and cerebrospinal fluid (meningitis), urine, bile, gallbladder wall, lungs, sputum, tonsils and mucous membrane of the sinus, atrium, kidneys, ureters, prostate, testes, uterus, fallopian tubes, bones, blood, umbilical cord and amniotic fluid.
The volume of distribution nandrolone, regardless of route of administration, 2.8-4.2 h hemodialysis, 2.2 h – in infants and children from 2 months. – 11 years. Excreted in the bile – 70-80%, the kidneys – 20-30% in unchanged form. In patients with impaired liver function and biliary tract obstruction , urinary excretion – 90% or more. Even under severe lesions in the liver bile therapeutic concentrations are achieved, and lengthened only 2-4 times. In patients with renal and hepatic impairment may accumulate.
- bacterial infections of the upper and lower respiratory tract;
- urinary tract infections;
- abdominal infections (peritonitis, cholecystitis, cholangitis and others.);
- Skin and soft tissue infections;
- infections of bones and joints;
- infectious and inflammatory diseases of the pelvic organs (including endometritis);
- gonorrhea and other genital tract infections;
- prevention of infectious nandrolone complications during abdominal, gynecological, cardiovascular and orthopedic surgery.
Hypersensitivity (including to other beta-lactam antibiotics).
Renal-hepatic failure, colitis in history.
Use during pregnancy and breast-feeding
Pregnant is used only on strict conditions, with the confidence that the potential benefits from the use of the mother outweighs the potential harm to the fetus. In the appointment during lactation should stop breastfeeding.
Dosage and administration
. Intravenous and intramuscular
. Adults – in the average daily dose of 4.2 grams, divided by two administration every 12 hours In severe infections the dose may be increased up to 12 g per day: 2-4 g every 8 h or 3-6 g every 12 hours. Treatment may be started before the results of the study the susceptibility of microorganisms. In uncomplicated gonococcal urethritis – intramuscularly at a dose of 500 mg.
Prevention of postoperative nandrolone complications: 1 g or 2 g / in 30-60 minutes prior to surgery, followed by repeated administration every 12 hours (usually within less than 24 h). When operating with an increased risk of infection (for example, operations in the colorectal area), open heart surgery, or prosthetic joints prophylactic application may continue for 72 hours after the operation.
In patients with a glomerular filtration rate below 18 ml / min or creatinine above 3 5 mg / dl – is not more than 4 grams per day.