In uncomplicated gonococcal urethritis recommended a one-time intramuscular injection of 500 mg of the drug. The drug is administered intramuscularly deep in the gluteus maximus muscle, or in the front of the thigh. When what is deca intravenously slow introduction of the maximum single dose of 2 g; administration duration – at least 3-5 min. The duration of intravenous drip -15-60 min.
Prevention of postoperative complications Assign 1 g or 2 g in / in 30-90 minutes prior to surgery, repeated every 12 hours (usually within less than 24 hours). In operations with an increased risk of infection (eg, operations in colorectal), or if arisen infection is particularly dangerous (for example, open-heart or prosthetic joints operations), the prophylactic use of the drug can last for 72 hours after completion of the operation. If any of the functions liver dose adjustment may be required in severe cases of severe obstruction of the bile ducts, severe liver disease or concomitant renal dysfunction. The daily dose should not exceed 2 g, with no need to monitor the serum concentration.If the what is decakidney function Because cefoperazone is mainly excreted through the kidneys are not, adjusting the dose (2-4 g / day) are required. Patients who have lower glomerular filtration rate of 18 ml / min, concentration or serum creatinine above 3.5 mg / dL, daily intake should not exceed 4 grams.
With hemodialysis cefoperazone half-life of blood serum, therefore, should be administered the drug decreases somewhat after the end of dialysis. if abnormal liver and kidney function should be monitored in the serum concentration of cefoperazone and adjust the dose if necessary. There is no need to control the concentration of serum provided that the daily dosage does not exceed 2 g Children 50-200 mg / kg body weight / day in equal parts (every 8-12 hours). The maximum dose is 12 g / day. When administered intravenously slow maximum single dose is 50 mg / kg body weight; Duration of administration -. at least 3-5 minutes Newborns (<8 days) . 50-200 mg / kg body weight / day in equal parts every 12 hoursPreparation of solutions Intramuscular To prepare solutions using sterile or bacteriostatic water for injection. If it is necessary to prepare a solution concentration of 250 mg / ml or more recommended dilution lidocaine solution, which is prepared by diluting a 2% lidocaine solution in sterile water for injection (approximate concentration of lidocaine hydrochloride in the resulting solution – 0.5%). Recommended preparation plant in two stages: 1) is first added required amount of sterile water for injection and stirred until complete dissolution of the powder, 2) then the required amount was added a 2% lidocaine solution, and stirred.
Contents of the vial is what is deca first diluted in either of the following solutions in compatible / injection (rate of at least 2.8 ml per 1 g of cefoperazone): 5% dextrose injection, a 10% dextrose solution for injection , 5% dextrose in 0.9% sodium chloride solution th injection, 0.9% sodium chloride solution th injection, Normosol M in the 5% dextrose solution for injection, 5% dextrose solution th 0.2% sodium chloride solution for injection, the R Normosol, sterile water for injection. To facilitate the dissolution is recommended to use 5 mL of solvent to 1 g of cefoperazone.
Then, the whole amount of the resulting solution is further diluted in one of the following solutions: 5% dextrose injection, a 10% dextrose solution for injection, 5% dextrose solution in Ringer’s lactate solution for injection, lactated Ringer’s solution, 0.9% sodium chloride th injection, 5% dextrose in 0.9% sodium chloride solution th injection, Normosol M in the 5% solution dextrose for injection, the R Normosol, 5% dextrose in 0.2% sodium chloride solution th injection.
contents of one vial is dissolved in 20-100 mL of a compatible sterile solution for the on / in the injections, using a sterile ., its volume of water should not exceed 20 ml
Prolonged intravenous infusion of
the contents of one vial (1 g) was dissolved in 5 ml of sterile water for injection or bacteriostatic water for injection; the resulting solution was added to a solution of the corresponding I / administration.
Intravenous administration of the slow jet
drug is dissolved in an what is deca appropriate solvent (final concentration 100 mg / ml) and administered for at least 3-5 min.